Most dangerous possible side effect

Tramadol can induce convulsions and boost the possibility of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic anti-depressants, anti-psychotics and also other seizure threshold lowering medicinal products(for example bupropion, mirtazapine, tehrahydrocannabinol) to cause convulsions.